Sceletium Tortuosum Overview

Unique selection of the South African plant Sceletium that is rich in mesembrenone, and low in mesembrine developed into a proprietary, standardized extract.

What It Does

Sceletium Tortuosum does more than act as an SSRI. Sceletium is also a PDE4 enzyme inhibitor. Certain enzymes constrict blood flow in the brain. The PDE4 enzyme inhibitor allows for easier vasodilation and blood flow which increases oxygen flow in the brain and body much like the male erectile dysfunction drug Viagra which is a PDE5 enzyme inhibitor. (Opium is a PDE10 enzyme inhibitor). Hence, the high serotonin re-uptake release combined with PDE4 inhibition allows one to experience a nice combination of stimulation and relaxation.

Sceletium Botony

  • Mesembryanthemaceae
  • Sceletium crassicaule
  • Sceletium emarcidum
  • Sceletium exalatum
  • Sceletium expansum
  • Sceletium rigidum
  • Sceletium strictum
  • Sceletium tortuosum
  • Sceletium varians

Current indigenous use of Sceletium

  • Stress – physical thirst, hunger
  • Stress – emotional arguments
  • Stress – colic & teething infants
  • Well-being – masticatory