Pharmacological Properties

Sceletium Tortuosum contains Mesembrine, which is a potent serotonin-uptake inhibitor with a novel mechanism of action for this known molecule, that suggests therapeutic applications for anxiety, depression and other serious mental health conditions.

Compounds: Sceletium tortuous contains mesembrine as the major alkaloid, together with mesembrenone, mesembrenol, and tortuosamine.

Therapeutic Indications: Anxiolytic

Dosage, Method, and Duration Administration:
In tablet form. a dose of 50 – 200 mg of the dried, powdered herb is included in tablets and capsules(about I – 4 mg of alkaloid) and taken two or three times a day. Traditionally, the dried product is regularly chewed throughout the day (the frequency is controlled by the slight hypnotic effect, similar to the practice of smoking tobacco). Teas,decoctions,and tinctures are also reported to be used,but details of dosage levels are unknown and/or unpublished.

Contraindications: Contraindicated when taking any psychiatric medication, including anti-psychotic drugs, monoamine oxidase inhibitors, serotonin-uptake inhibitors, and benzodiazepine.

Special Warnings and Precautions for Use: None. Can be safely consumed when used appropriately.

Interactions: None known.

Adverse Effects: Occasional side-effects include self-limiting headache,mild loose stools,mild abdominal cramping, sedation,and stimulation.

Evaluation of Efficacy: Sedative (anxiety, stress) efficacy pharmacologically proven. Relaxant efficacy pharmacologically proven.